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Moreover, this market preference also stems from its status as the only U.S.FDA-approved maintenance dose specifically indicated for long-term obesity treatment

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Tirzepatide may also increase the risk of gallbladder disease, including cholelithiasis and cholecystitis

However, in most trials, participants received metformin, either as monotherapy or in combination with other agents, except for three trials where participants received no background glucose-lowering therapy after randomisation [26, 40, 49]